Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 843995..844536 Replicon chromosome
Accession NZ_CP104598
Organism Escherichia coli strain AHM8C160RI

Toxin (Protein)


Gene name yafQ Uniprot ID A0A246NT41
Locus tag N5861_RS04010 Protein ID WP_000615977.1
Coordinates 843995..844273 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag N5861_RS04015 Protein ID WP_000729709.1
Coordinates 844276..844536 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5861_RS03995 (841577) 841577..842155 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
N5861_RS04000 (842361) 842361..843128 + 768 WP_094317940.1 class II glutamine amidotransferase -
N5861_RS04005 (843099) 843099..843839 - 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N5861_RS04010 (843995) 843995..844273 - 279 WP_000615977.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N5861_RS04015 (844276) 844276..844536 - 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N5861_RS04020 (844746) 844746..845495 + 750 WP_094317939.1 C40 family peptidase -
N5861_RS04025 (845671) 845671..846168 + 498 WP_000006266.1 REP-associated tyrosine transposase RayT -
N5861_RS04030 (846354) 846354..848447 - 2094 WP_097702245.1 flagellar biosynthesis protein FlhA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 816507..846168 29661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10842.67 Da        Isoelectric Point: 10.0702

>T258549 WP_000615977.1 NZ_CP104598:c844273-843995 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNILPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT258549 WP_000729709.1 NZ_CP104598:c844536-844276 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246NT41

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References