Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 602957..603756 Replicon chromosome
Accession NZ_CP104595
Organism Escherichia coli strain EC9952

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag N5B57_RS02930 Protein ID WP_000347267.1
Coordinates 602957..603421 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N5B57_RS02935 Protein ID WP_001307405.1
Coordinates 603421..603756 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5B57_RS02900 (597958) 597958..598392 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N5B57_RS02905 (598410) 598410..599288 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
N5B57_RS02910 (599278) 599278..600057 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N5B57_RS02915 (600068) 600068..600541 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N5B57_RS02920 (600564) 600564..601844 - 1281 WP_195717708.1 tagatose-bisphosphate aldolase subunit KbaZ -
N5B57_RS02925 (602093) 602093..602902 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N5B57_RS02930 (602957) 602957..603421 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N5B57_RS02935 (603421) 603421..603756 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N5B57_RS02940 (603905) 603905..605476 - 1572 WP_001273741.1 galactarate dehydratase -
N5B57_RS02945 (605851) 605851..607185 + 1335 WP_087889555.1 galactarate/glucarate/glycerate transporter GarP -
N5B57_RS02950 (607201) 607201..607971 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T258521 WP_000347267.1 NZ_CP104595:c603421-602957 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp


Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT258521 WP_001307405.1 NZ_CP104595:c603756-603421 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References