Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3365563..3366158 Replicon chromosome
Accession NZ_CP104590
Organism Pseudomonas aeruginosa strain WTJH36

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag N5878_RS15785 Protein ID WP_003117425.1
Coordinates 3365880..3366158 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5878_RS15780 Protein ID WP_003099268.1
Coordinates 3365563..3365868 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5878_RS15745 (N5878_15745) 3361016..3361306 - 291 WP_023083237.1 DUF5447 family protein -
N5878_RS15750 (N5878_15750) 3361310..3361525 - 216 WP_031629304.1 hypothetical protein -
N5878_RS15755 (N5878_15755) 3361518..3361790 - 273 WP_003115921.1 hypothetical protein -
N5878_RS15760 (N5878_15760) 3361900..3362166 + 267 WP_016852153.1 hypothetical protein -
N5878_RS15765 (N5878_15765) 3362298..3363134 + 837 WP_223656480.1 helix-turn-helix domain-containing protein -
N5878_RS15770 (N5878_15770) 3363109..3364647 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
N5878_RS15775 (N5878_15775) 3364659..3365186 - 528 WP_071535723.1 ATP-binding protein -
N5878_RS15780 (N5878_15780) 3365563..3365868 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
N5878_RS15785 (N5878_15785) 3365880..3366158 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5878_RS15790 (N5878_15790) 3366211..3366339 - 129 Protein_3122 integrase -
N5878_RS15795 (N5878_15795) 3366487..3368715 + 2229 WP_003099265.1 TonB-dependent receptor -
N5878_RS15800 (N5878_15800) 3368785..3369432 - 648 WP_003095021.1 carbonate dehydratase -
N5878_RS15805 (N5878_15805) 3369494..3370732 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T258513 WP_003117425.1 NZ_CP104590:c3366158-3365880 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT258513 WP_003099268.1 NZ_CP104590:c3365868-3365563 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References