Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5863145..5863740 Replicon chromosome
Accession NZ_CP104588
Organism Pseudomonas aeruginosa strain WTJH32

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag N5879_RS27325 Protein ID WP_003117425.1
Coordinates 5863462..5863740 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5879_RS27320 Protein ID WP_003099268.1
Coordinates 5863145..5863450 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5879_RS27290 (N5879_27290) 5858598..5858888 - 291 WP_023083237.1 DUF5447 family protein -
N5879_RS27295 (N5879_27295) 5859100..5859372 - 273 WP_003115921.1 hypothetical protein -
N5879_RS27300 (N5879_27300) 5859482..5859748 + 267 WP_016852153.1 hypothetical protein -
N5879_RS27305 (N5879_27305) 5859880..5860716 + 837 WP_223656480.1 helix-turn-helix domain-containing protein -
N5879_RS27310 (N5879_27310) 5860691..5862229 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
N5879_RS27315 (N5879_27315) 5862241..5862768 - 528 WP_071535723.1 ATP-binding protein -
N5879_RS27320 (N5879_27320) 5863145..5863450 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
N5879_RS27325 (N5879_27325) 5863462..5863740 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5879_RS27330 (N5879_27330) 5863793..5863921 - 129 Protein_5403 integrase -
N5879_RS27335 (N5879_27335) 5864069..5866297 + 2229 WP_003099265.1 TonB-dependent receptor -
N5879_RS27340 (N5879_27340) 5866367..5867014 - 648 WP_003095021.1 carbonate dehydratase -
N5879_RS27345 (N5879_27345) 5867076..5868314 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T258509 WP_003117425.1 NZ_CP104588:c5863740-5863462 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT258509 WP_003099268.1 NZ_CP104588:c5863450-5863145 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References