Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4926513..4927194 Replicon chromosome
Accession NZ_CP104586
Organism Pseudomonas aeruginosa strain WTJH6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5877_RS22810 Protein ID WP_015503432.1
Coordinates 4926513..4926878 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5877_RS22815 Protein ID WP_016561576.1
Coordinates 4926871..4927194 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5877_RS22780 (N5877_22780) 4922518..4922952 - 435 WP_003158601.1 RidA family protein -
N5877_RS22785 (N5877_22785) 4923173..4924126 + 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
N5877_RS22790 (N5877_22790) 4924099..4924983 - 885 WP_019725847.1 LysR substrate-binding domain-containing protein -
N5877_RS22795 (N5877_22795) 4925084..4925509 + 426 WP_003163196.1 VOC family protein -
N5877_RS22800 (N5877_22800) 4925528..4925800 - 273 WP_003085667.1 hypothetical protein -
N5877_RS22805 (N5877_22805) 4926007..4926249 + 243 WP_043884955.1 hypothetical protein -
N5877_RS22810 (N5877_22810) 4926513..4926878 + 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5877_RS22815 (N5877_22815) 4926871..4927194 + 324 WP_016561576.1 XRE family transcriptional regulator Antitoxin
N5877_RS22820 (N5877_22820) 4927310..4927429 - 120 Protein_4495 IS5/IS1182 family transposase -
N5877_RS22825 (N5877_22825) 4927424..4927816 + 393 Protein_4496 hypothetical protein -
N5877_RS22830 (N5877_22830) 4927816..4928819 + 1004 Protein_4497 tyrosine-type recombinase/integrase -
N5877_RS22835 (N5877_22835) 4929036..4929287 + 252 WP_124136459.1 hypothetical protein -
N5877_RS22840 (N5877_22840) 4929317..4930183 + 867 WP_023081971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T258497 WP_015503432.1 NZ_CP104586:4926513-4926878 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 5.8900

>AT258497 WP_016561576.1 NZ_CP104586:4926871-4927194 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQSRGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References