Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5869589..5870184 Replicon chromosome
Accession NZ_CP104584
Organism Pseudomonas aeruginosa strain WTJH2

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag N5876_RS27375 Protein ID WP_003117425.1
Coordinates 5869906..5870184 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5876_RS27370 Protein ID WP_003099268.1
Coordinates 5869589..5869894 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5876_RS27340 (N5876_27340) 5865042..5865332 - 291 WP_023083237.1 DUF5447 family protein -
N5876_RS27345 (N5876_27345) 5865544..5865816 - 273 WP_003115921.1 hypothetical protein -
N5876_RS27350 (N5876_27350) 5865926..5866192 + 267 WP_016852153.1 hypothetical protein -
N5876_RS27355 (N5876_27355) 5866324..5867160 + 837 WP_223656480.1 helix-turn-helix domain-containing protein -
N5876_RS27360 (N5876_27360) 5867135..5868673 + 1539 WP_023082696.1 GNAT family N-acetyltransferase -
N5876_RS27365 (N5876_27365) 5868685..5869212 - 528 WP_071535723.1 ATP-binding protein -
N5876_RS27370 (N5876_27370) 5869589..5869894 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
N5876_RS27375 (N5876_27375) 5869906..5870184 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5876_RS27380 (N5876_27380) 5870237..5870365 - 129 Protein_5413 integrase -
N5876_RS27385 (N5876_27385) 5870513..5872741 + 2229 WP_003099265.1 TonB-dependent receptor -
N5876_RS27390 (N5876_27390) 5872811..5873458 - 648 WP_003095021.1 carbonate dehydratase -
N5876_RS27395 (N5876_27395) 5873520..5874758 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T258491 WP_003117425.1 NZ_CP104584:c5870184-5869906 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT258491 WP_003099268.1 NZ_CP104584:c5869894-5869589 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References