Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2495848..2496350 Replicon chromosome
Accession NZ_CP104583
Organism Pseudomonas sp. GD03721

Toxin (Protein)


Gene name yoeB Uniprot ID A0A235EZL9
Locus tag N5O88_RS12090 Protein ID WP_075117074.1
Coordinates 2495848..2496102 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A235F1E0
Locus tag N5O88_RS12095 Protein ID WP_075117073.1
Coordinates 2496099..2496350 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O88_RS12065 (N5O88_12070) 2491366..2492229 + 864 WP_094267734.1 integrase domain-containing protein -
N5O88_RS12070 (N5O88_12075) 2492237..2493034 - 798 WP_102053793.1 hypothetical protein -
N5O88_RS12075 (N5O88_12080) 2493348..2493698 + 351 WP_094267732.1 hypothetical protein -
N5O88_RS12080 (N5O88_12085) 2493714..2495234 + 1521 WP_102053794.1 conjugal transfer protein TraG N-terminal domain-containing protein -
N5O88_RS12085 (N5O88_12090) 2495242..2495631 - 390 WP_094267730.1 DUF3742 family protein -
N5O88_RS12090 (N5O88_12095) 2495848..2496102 - 255 WP_075117074.1 Txe/YoeB family addiction module toxin Toxin
N5O88_RS12095 (N5O88_12100) 2496099..2496350 - 252 WP_075117073.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N5O88_RS12100 (N5O88_12105) 2496583..2497815 - 1233 Protein_2374 tyrosine-type recombinase/integrase -
N5O88_RS12110 (N5O88_12115) 2498184..2498744 - 561 WP_279530466.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
N5O88_RS12115 (N5O88_12120) 2498778..2500601 - 1824 WP_279530467.1 excinuclease ABC subunit UvrC -
N5O88_RS12120 (N5O88_12125) 2500604..2501248 - 645 WP_279530468.1 UvrY/SirA/GacA family response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10170.65 Da        Isoelectric Point: 9.4089

>T258482 WP_075117074.1 NZ_CP104583:c2496102-2495848 [Pseudomonas sp. GD03721]
VKLIWSEQAWDDYLYWQEADKRMVKKLNELIKETRRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDEALLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9391.61 Da        Isoelectric Point: 4.5843

>AT258482 WP_075117073.1 NZ_CP104583:c2496350-2496099 [Pseudomonas sp. GD03721]
MRTISYTEARQNLSATMVQTVEDRVPTLITRQNGEACVLMSLEEYNALEETAYLLRSPANARRLMDSIDSLKRGQGVERD
IAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A235EZL9

Antitoxin

Source ID Structure
AlphaFold DB A0A235F1E0

References