Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 289329..289952 Replicon chromosome
Accession NZ_CP104581
Organism Delftia tsuruhatensis strain GD03927

Toxin (Protein)


Gene name higB Uniprot ID A0A1I1B5B2
Locus tag N5O86_RS01275 Protein ID WP_016448670.1
Coordinates 289329..289610 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5O86_RS01280 Protein ID WP_013800141.1
Coordinates 289653..289952 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O86_RS01250 (N5O86_01250) 284685..285548 + 864 WP_279493882.1 branched-chain amino acid ABC transporter permease -
N5O86_RS01255 (N5O86_01255) 285549..286523 + 975 WP_043792260.1 branched-chain amino acid ABC transporter permease -
N5O86_RS01260 (N5O86_01260) 286510..287274 + 765 WP_016452146.1 ABC transporter ATP-binding protein -
N5O86_RS01265 (N5O86_01265) 287261..287968 + 708 WP_016448672.1 ABC transporter ATP-binding protein -
N5O86_RS01270 (N5O86_01270) 288024..289199 + 1176 WP_016452145.1 ABC transporter substrate-binding protein -
N5O86_RS01275 (N5O86_01275) 289329..289610 + 282 WP_016448670.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O86_RS01280 (N5O86_01280) 289653..289952 + 300 WP_013800141.1 HigA family addiction module antitoxin Antitoxin
N5O86_RS01285 (N5O86_01285) 290045..290818 - 774 WP_279493883.1 SDR family oxidoreductase -
N5O86_RS01290 (N5O86_01290) 290964..291770 - 807 WP_016448668.1 IclR family transcriptional regulator -
N5O86_RS01295 (N5O86_01295) 291815..292588 - 774 WP_016448667.1 ferredoxin--NADP reductase -
N5O86_RS01300 (N5O86_01300) 292850..293785 - 936 WP_279493884.1 LysR family transcriptional regulator -
N5O86_RS01305 (N5O86_01305) 293878..294669 + 792 WP_279493885.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11057.71 Da        Isoelectric Point: 10.1057

>T258462 WP_016448670.1 NZ_CP104581:289329-289610 [Delftia tsuruhatensis]
MTIQSFKCPDTEQLFQQRRVRRWSSIEVVALRKLRMLHAAHVLQDLRVPPGNRLEALQGDRKGQHSIRINDQWRVCFVWT
HEGPSQLEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10990.57 Da        Isoelectric Point: 4.5183

>AT258462 WP_013800141.1 NZ_CP104581:289653-289952 [Delftia tsuruhatensis]
MNKPLNLPTPGEILATEFLEPMGLTQYRLAQAIHVPQTRIAAIVKNGRSITADTALRLARFFGTSVEFWMNLQSQYDADI
AREAIGDDLESIEPFALQA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I1B5B2

Antitoxin

Source ID Structure

References