Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 732894..733669 Replicon chromosome
Accession NZ_CP104551
Organism Klebsiella pneumoniae strain K28074

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag N5911_RS03670 Protein ID WP_004150910.1
Coordinates 733184..733669 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag N5911_RS03665 Protein ID WP_004150912.1
Coordinates 732894..733187 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5911_RS03645 (N5911_03645) 728102..728704 - 603 WP_062954968.1 short chain dehydrogenase -
N5911_RS03650 (N5911_03650) 728802..729713 + 912 WP_004188550.1 LysR family transcriptional regulator -
N5911_RS03655 (N5911_03655) 729714..730862 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
N5911_RS03660 (N5911_03660) 730873..732249 - 1377 WP_004217775.1 cystathionine beta-synthase -
N5911_RS03665 (N5911_03665) 732894..733187 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
N5911_RS03670 (N5911_03670) 733184..733669 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
N5911_RS03675 (N5911_03675) 734373..734966 + 594 WP_004188553.1 hypothetical protein -
N5911_RS03680 (N5911_03680) 735063..735279 + 217 Protein_723 transposase -
N5911_RS03685 (N5911_03685) 735885..736757 + 873 WP_004188557.1 ParA family protein -
N5911_RS03690 (N5911_03690) 736757..737140 + 384 WP_004150906.1 hypothetical protein -
N5911_RS03695 (N5911_03695) 737133..738500 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 735063..735215 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T258412 WP_004150910.1 NZ_CP104551:733184-733669 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT258412 WP_004150912.1 NZ_CP104551:732894-733187 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References