258381

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3835492..3836033 Replicon chromosome
Accession NZ_CP104539
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag N5O76_RS18805 Protein ID WP_000615976.1
Coordinates 3835755..3836033 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag N5O76_RS18800 Protein ID WP_000729704.1
Coordinates 3835492..3835752 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS18775 (3831275) 3831275..3832060 - 786 WP_000207557.1 putative lateral flagellar export/assembly protein LafU -
N5O76_RS18780 (3832032) 3832032..3833744 + 1713 Protein_3678 flagellar biosynthesis protein FlhA -
N5O76_RS18785 (3833849) 3833849..3834127 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
N5O76_RS18790 (3834120) 3834120..3834476 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
N5O76_RS18795 (3834533) 3834533..3835306 - 774 WP_000543897.1 C40 family peptidase -
N5O76_RS18800 (3835492) 3835492..3835752 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N5O76_RS18805 (3835755) 3835755..3836033 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N5O76_RS18810 (3836189) 3836189..3836929 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N5O76_RS18815 (3836900) 3836900..3837667 - 768 WP_000333380.1 class II glutamine amidotransferase -
N5O76_RS18820 (3837873) 3837873..3838451 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T258381 WP_000615976.1 NZ_CP104539:3835755-3836033 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT258381 WP_000729704.1 NZ_CP104539:3835492-3835752 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References