Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1887941..1888443 Replicon chromosome
Accession NZ_CP104539
Organism Escherichia coli strain E6

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag N5O76_RS09095 Protein ID WP_001570036.1
Coordinates 1888189..1888443 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N5O76_RS09090 Protein ID WP_001259255.1
Coordinates 1887941..1888192 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O76_RS09065 (1883119) 1883119..1884186 - 1068 WP_029392100.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N5O76_RS09070 (1884186) 1884186..1885256 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
N5O76_RS09075 (1885253) 1885253..1886557 - 1305 WP_029402287.1 histidinol dehydrogenase -
N5O76_RS09080 (1886563) 1886563..1887462 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
N5O76_RS09085 (1887608) 1887608..1887658 - 51 WP_001364200.1 his operon leader peptide -
N5O76_RS09090 (1887941) 1887941..1888192 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N5O76_RS09095 (1888189) 1888189..1888443 + 255 WP_001570036.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N5O76_RS09100 (1888526) 1888526..1889350 + 825 WP_000754758.1 SDR family oxidoreductase -
N5O76_RS09105 (1889396) 1889396..1890325 + 930 WP_261306662.1 LysR substrate-binding domain-containing protein -
N5O76_RS09110 (1890540) 1890540..1890602 + 63 WP_010723108.1 membrane protein YoeI -
N5O76_RS09115 (1890592) 1890592..1891950 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N5O76_RS09120 (1892129) 1892129..1893187 + 1059 WP_023568741.1 thiosulfate utilization transporter TsuA/YeeE -
N5O76_RS09125 (1893201) 1893201..1893428 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10199.63 Da        Isoelectric Point: 8.0353

>T258373 WP_001570036.1 NZ_CP104539:1888189-1888443 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTLFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT258373 WP_001259255.1 NZ_CP104539:1887941-1888192 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References