Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 733710..734403 Replicon chromosome
Accession NZ_CP104536
Organism Escherichia coli strain E3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N5O72_RS03620 Protein ID WP_000415584.1
Coordinates 733710..734006 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N5O72_RS03625 Protein ID WP_000650107.1
Coordinates 734008..734403 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O72_RS03590 (729385) 729385..729699 - 315 WP_000958598.1 putative quinol monooxygenase -
N5O72_RS03595 (729730) 729730..730311 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
N5O72_RS03600 (730421) 730421..731770 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
N5O72_RS03605 (731767) 731767..732426 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
N5O72_RS03610 (732578) 732578..732970 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N5O72_RS03615 (733023) 733023..733505 + 483 WP_000183494.1 GyrI-like domain-containing protein -
N5O72_RS03620 (733710) 733710..734006 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N5O72_RS03625 (734008) 734008..734403 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N5O72_RS03630 (734536) 734536..736143 + 1608 WP_001701096.1 ABC transporter substrate-binding protein -
N5O72_RS03635 (736281) 736281..738539 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 721982..734403 12421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T258350 WP_000415584.1 NZ_CP104536:733710-734006 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT258350 WP_000650107.1 NZ_CP104536:734008-734403 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References