258340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4870432..4871034 Replicon chromosome
Accession NZ_CP104533
Organism Escherichia coli strain E10

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag N5O77_RS24105 Protein ID WP_000897302.1
Coordinates 4870723..4871034 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5O77_RS24100 Protein ID WP_000356397.1
Coordinates 4870432..4870722 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O77_RS24075 (4866505) 4866505..4867407 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
N5O77_RS24080 (4867404) 4867404..4868039 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N5O77_RS24085 (4868036) 4868036..4868965 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
N5O77_RS24090 (4869181) 4869181..4869399 - 219 WP_001314326.1 CopG family transcriptional regulator -
N5O77_RS24095 (4869795) 4869795..4870073 - 279 WP_001296612.1 hypothetical protein -
N5O77_RS24100 (4870432) 4870432..4870722 - 291 WP_000356397.1 NadS family protein Antitoxin
N5O77_RS24105 (4870723) 4870723..4871034 - 312 WP_000897302.1 hypothetical protein Toxin
N5O77_RS24110 (4871263) 4871263..4872171 + 909 WP_001331553.1 alpha/beta hydrolase -
N5O77_RS24115 (4872235) 4872235..4873176 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N5O77_RS24120 (4873221) 4873221..4873658 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N5O77_RS24125 (4873655) 4873655..4874527 - 873 WP_261175552.1 virulence factor BrkB family protein -
N5O77_RS24130 (4874521) 4874521..4875120 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T258340 WP_000897302.1 NZ_CP104533:c4871034-4870723 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT258340 WP_000356397.1 NZ_CP104533:c4870722-4870432 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References