258328

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2539271..2539833 Replicon chromosome
Accession NZ_CP104533
Organism Escherichia coli strain E10

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag N5O77_RS12505 Protein ID WP_000605675.1
Coordinates 2539271..2539549 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag N5O77_RS12510 Protein ID WP_000781370.1
Coordinates 2539549..2539833 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O77_RS12480 (2534858) 2534858..2535289 - 432 WP_000152310.1 peroxiredoxin OsmC -
N5O77_RS12485 (2535634) 2535634..2535849 + 216 WP_000495766.1 biofilm-dependent modulation protein -
N5O77_RS12490 (2535951) 2535951..2536088 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
N5O77_RS12495 (2536244) 2536244..2537941 + 1698 WP_000433462.1 malate dehydrogenase -
N5O77_RS12500 (2538075) 2538075..2539085 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
N5O77_RS12505 (2539271) 2539271..2539549 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5O77_RS12510 (2539549) 2539549..2539833 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
N5O77_RS12515 (2540062) 2540062..2540715 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
N5O77_RS12520 (2540708) 2540708..2541592 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
N5O77_RS12525 (2541605) 2541605..2544652 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T258328 WP_000605675.1 NZ_CP104533:2539271-2539549 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT258328 WP_000781370.1 NZ_CP104533:2539549-2539833 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CUG6

References