258321

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1971518..1972020 Replicon chromosome
Accession NZ_CP104533
Organism Escherichia coli strain E10

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N5O77_RS09545 Protein ID WP_000767829.1
Coordinates 1971766..1972020 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N5O77_RS09540 Protein ID WP_001259255.1
Coordinates 1971518..1971769 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O77_RS09515 (1966696) 1966696..1967763 - 1068 WP_001513846.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N5O77_RS09520 (1967763) 1967763..1968833 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
N5O77_RS09525 (1968830) 1968830..1970134 - 1305 WP_001513845.1 histidinol dehydrogenase -
N5O77_RS09530 (1970140) 1970140..1971039 - 900 WP_000131789.1 ATP phosphoribosyltransferase -
N5O77_RS09535 (1971185) 1971185..1971235 - 51 WP_071593552.1 his operon leader peptide -
N5O77_RS09540 (1971518) 1971518..1971769 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N5O77_RS09545 (1971766) 1971766..1972020 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N5O77_RS09550 (1972103) 1972103..1972927 + 825 WP_000754737.1 SDR family oxidoreductase -
N5O77_RS09555 (1972973) 1972973..1973902 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N5O77_RS09560 (1974117) 1974117..1974179 + 63 WP_010723108.1 membrane protein YoeI -
N5O77_RS09565 (1974169) 1974169..1975527 + 1359 WP_059228986.1 putrescine/proton symporter PlaP -
N5O77_RS09570 (1975706) 1975706..1976764 + 1059 WP_000492340.1 thiosulfate utilization transporter TsuA/YeeE -
N5O77_RS09575 (1976778) 1976778..1977005 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T258321 WP_000767829.1 NZ_CP104533:1971766-1972020 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT258321 WP_001259255.1 NZ_CP104533:1971518-1971769 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References