Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 728944..729637 Replicon chromosome
Accession NZ_CP104526
Organism Escherichia coli strain E8

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N5O73_RS03545 Protein ID WP_000415584.1
Coordinates 728944..729240 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N5O73_RS03550 Protein ID WP_000650107.1
Coordinates 729242..729637 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O73_RS03510 (724032) 724032..724346 - 315 WP_000958598.1 putative quinol monooxygenase -
N5O73_RS03515 (724377) 724377..724958 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
N5O73_RS03520 (725277) 725277..725609 + 333 WP_000917684.1 DUF2645 family protein -
N5O73_RS03525 (725655) 725655..727004 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
N5O73_RS03530 (727001) 727001..727660 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
N5O73_RS03535 (727812) 727812..728204 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N5O73_RS03540 (728257) 728257..728739 + 483 WP_000183505.1 GyrI-like domain-containing protein -
N5O73_RS03545 (728944) 728944..729240 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N5O73_RS03550 (729242) 729242..729637 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N5O73_RS03555 (729770) 729770..731377 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
N5O73_RS03560 (731515) 731515..733773 + 2259 WP_001618856.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T258298 WP_000415584.1 NZ_CP104526:728944-729240 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT258298 WP_000650107.1 NZ_CP104526:729242-729637 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References