Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2910866..2911368 Replicon chromosome
Accession NZ_CP104523
Organism Escherichia coli strain E7

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag N5O80_RS14440 Protein ID WP_000767820.1
Coordinates 2910866..2911120 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N5O80_RS14445 Protein ID WP_001259255.1
Coordinates 2911117..2911368 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O80_RS14410 (2905881) 2905881..2906108 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
N5O80_RS14415 (2906122) 2906122..2907180 - 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
N5O80_RS14420 (2907359) 2907359..2908717 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N5O80_RS14425 (2908707) 2908707..2908769 - 63 WP_010723108.1 membrane protein YoeI -
N5O80_RS14430 (2908984) 2908984..2909913 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N5O80_RS14435 (2909959) 2909959..2910783 - 825 WP_000754756.1 SDR family oxidoreductase -
N5O80_RS14440 (2910866) 2910866..2911120 - 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N5O80_RS14445 (2911117) 2911117..2911368 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N5O80_RS14450 (2911652) 2911652..2911702 + 51 WP_001364200.1 his operon leader peptide -
N5O80_RS14455 (2911848) 2911848..2912747 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
N5O80_RS14460 (2912753) 2912753..2914057 + 1305 WP_039025710.1 histidinol dehydrogenase -
N5O80_RS14465 (2914054) 2914054..2915124 + 1071 WP_000108952.1 histidinol-phosphate transaminase -
N5O80_RS14470 (2915124) 2915124..2916191 + 1068 WP_000080077.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T258279 WP_000767820.1 NZ_CP104523:c2911120-2910866 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT258279 WP_001259255.1 NZ_CP104523:c2911368-2911117 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References