Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3956926..3957619 Replicon chromosome
Accession NZ_CP104516
Organism Escherichia coli strain E4

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N5O79_RS19750 Protein ID WP_000415584.1
Coordinates 3956926..3957222 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N5O79_RS19755 Protein ID WP_000650107.1
Coordinates 3957224..3957619 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O79_RS19715 (3952014) 3952014..3952328 - 315 WP_000958598.1 putative quinol monooxygenase -
N5O79_RS19720 (3952359) 3952359..3952940 - 582 Protein_3853 NADPH:quinone oxidoreductase MdaB -
N5O79_RS19725 (3953259) 3953259..3953591 + 333 WP_000917684.1 DUF2645 family protein -
N5O79_RS19730 (3953637) 3953637..3954986 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
N5O79_RS19735 (3954983) 3954983..3955642 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
N5O79_RS19740 (3955794) 3955794..3956186 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N5O79_RS19745 (3956239) 3956239..3956721 + 483 WP_000183505.1 GyrI-like domain-containing protein -
N5O79_RS19750 (3956926) 3956926..3957222 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N5O79_RS19755 (3957224) 3957224..3957619 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N5O79_RS19760 (3957752) 3957752..3959359 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
N5O79_RS19765 (3959497) 3959497..3961755 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T258229 WP_000415584.1 NZ_CP104516:3956926-3957222 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT258229 WP_000650107.1 NZ_CP104516:3957224-3957619 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References