Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4195291..4195984 Replicon chromosome
Accession NZ_CP104509
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N5O74_RS21255 Protein ID WP_000415584.1
Coordinates 4195688..4195984 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N5O74_RS21250 Protein ID WP_000650107.1
Coordinates 4195291..4195686 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O74_RS21240 (4191155) 4191155..4193413 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
N5O74_RS21245 (4193551) 4193551..4195158 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
N5O74_RS21250 (4195291) 4195291..4195686 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N5O74_RS21255 (4195688) 4195688..4195984 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N5O74_RS21260 (4196189) 4196189..4196614 - 426 WP_222890937.1 GyrI-like domain-containing protein -
N5O74_RS21265 (4196672) 4196672..4197880 - 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -
N5O74_RS21270 (4198062) 4198062..4198454 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N5O74_RS21275 (4198606) 4198606..4199265 + 660 WP_001221487.1 quorum sensing response regulator transcription factor QseB -
N5O74_RS21280 (4199262) 4199262..4200611 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4196672..4197880 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T258202 WP_000415584.1 NZ_CP104509:c4195984-4195688 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT258202 WP_000650107.1 NZ_CP104509:c4195686-4195291 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References