258197

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2941785..2942287 Replicon chromosome
Accession NZ_CP104509
Organism Escherichia coli strain E2

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N5O74_RS14975 Protein ID WP_000767829.1
Coordinates 2941785..2942039 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N5O74_RS14980 Protein ID WP_001259255.1
Coordinates 2942036..2942287 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O74_RS14945 (2936800) 2936800..2937027 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
N5O74_RS14950 (2937041) 2937041..2938099 - 1059 WP_000492324.1 thiosulfate utilization transporter TsuA/YeeE -
N5O74_RS14955 (2938278) 2938278..2939636 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N5O74_RS14960 (2939626) 2939626..2939688 - 63 WP_010723108.1 membrane protein YoeI -
N5O74_RS14965 (2939903) 2939903..2940832 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N5O74_RS14970 (2940878) 2940878..2941702 - 825 WP_000754758.1 SDR family oxidoreductase -
N5O74_RS14975 (2941785) 2941785..2942039 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N5O74_RS14980 (2942036) 2942036..2942287 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N5O74_RS14985 (2942570) 2942570..2942620 + 51 WP_001364200.1 his operon leader peptide -
N5O74_RS14990 (2942766) 2942766..2943665 + 900 WP_000131756.1 ATP phosphoribosyltransferase -
N5O74_RS14995 (2943671) 2943671..2944975 + 1305 WP_001442151.1 histidinol dehydrogenase -
N5O74_RS15000 (2944972) 2944972..2946042 + 1071 WP_000108960.1 histidinol-phosphate transaminase -
N5O74_RS15005 (2946042) 2946042..2947109 + 1068 WP_192954971.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T258197 WP_000767829.1 NZ_CP104509:c2942039-2941785 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT258197 WP_001259255.1 NZ_CP104509:c2942287-2942036 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References