Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 1437883..1438531 Replicon chromosome
Accession NC_016768
Organism Mycobacterium tuberculosis KZN 4207

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag TBSG_RS06840 Protein ID WP_003899414.1
Coordinates 1438208..1438531 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag TBSG_RS06835 Protein ID WP_003899415.1
Coordinates 1437883..1438128 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBSG_RS06795 1433031..1433264 - 234 WP_003413717.1 hypothetical protein -
TBSG_RS06800 1433363..1433635 - 273 WP_003900544.1 hypothetical protein -
TBSG_RS21010 1433541..1433930 + 390 WP_003899422.1 hypothetical protein -
TBSG_RS06805 1433927..1434154 + 228 WP_003899421.1 hypothetical protein -
TBSG_RS06810 1434299..1435426 + 1128 WP_003899420.1 site-specific integrase -
TBSG_RS06815 1435429..1435791 + 363 WP_003900543.1 hypothetical protein -
TBSG_RS06820 1435808..1436068 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
TBSG_RS06825 1436065..1436457 + 393 WP_003899417.1 DUF2742 domain-containing protein -
TBSG_RS06830 1436459..1437886 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
TBSG_RS06835 1437883..1438128 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
TBSG_RS06840 1438208..1438531 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
TBSG_RS21015 1438698..1439189 + 492 WP_003900541.1 phage terminase small subunit P27 family -
TBSG_RS06850 1439342..1439875 + 534 WP_003899412.1 HK97 family phage prohead protease -
TBSG_RS06855 1439883..1441322 + 1440 WP_003899411.1 phage major capsid protein -
TBSG_RS06860 1441493..1441744 - 252 WP_003908028.1 hypothetical protein -
TBSG_RS06865 1441732..1442196 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
TBSG_RS06870 1442210..1443208 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1434299..1443208 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T25818 WP_003899414.1 NC_016768:1438208-1438531 [Mycobacterium tuberculosis KZN 4207]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T25818 NC_016768:1438208-1438531 [Mycobacterium tuberculosis KZN 4207]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT25818 WP_003899415.1 NC_016768:1437883-1438128 [Mycobacterium tuberculosis KZN 4207]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT25818 NC_016768:1437883-1438128 [Mycobacterium tuberculosis KZN 4207]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References