Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 3298264..3298866 Replicon chromosome
Accession NZ_CP104503
Organism Escherichia coli strain E1

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag N5O81_RS15995 Protein ID WP_000897302.1
Coordinates 3298264..3298575 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5O81_RS16000 Protein ID WP_000356397.1
Coordinates 3298576..3298866 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O81_RS15970 (3294178) 3294178..3294777 + 600 WP_001314324.1 glucose-1-phosphatase -
N5O81_RS15975 (3294771) 3294771..3295643 + 873 WP_000920762.1 virulence factor BrkB family protein -
N5O81_RS15980 (3295640) 3295640..3296077 + 438 WP_000560990.1 D-aminoacyl-tRNA deacylase -
N5O81_RS15985 (3296122) 3296122..3297063 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N5O81_RS15990 (3297127) 3297127..3298035 - 909 WP_001331553.1 alpha/beta hydrolase -
N5O81_RS15995 (3298264) 3298264..3298575 + 312 WP_000897302.1 hypothetical protein Toxin
N5O81_RS16000 (3298576) 3298576..3298866 + 291 WP_000356397.1 NadS family protein Antitoxin
N5O81_RS16005 (3299225) 3299225..3299503 + 279 WP_001296612.1 hypothetical protein -
N5O81_RS16010 (3299899) 3299899..3300117 + 219 WP_001314326.1 CopG family transcriptional regulator -
N5O81_RS16015 (3300333) 3300333..3301262 - 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
N5O81_RS16020 (3301259) 3301259..3301894 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N5O81_RS16025 (3301891) 3301891..3302793 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T258170 WP_000897302.1 NZ_CP104503:3298264-3298575 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT258170 WP_000356397.1 NZ_CP104503:3298576-3298866 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References