Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2484438..2485237 Replicon chromosome
Accession NZ_CP104503
Organism Escherichia coli strain E1

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag N5O81_RS12030 Protein ID WP_000347251.1
Coordinates 2484773..2485237 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag N5O81_RS12025 Protein ID WP_001296435.1
Coordinates 2484438..2484773 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O81_RS12010 (2480223) 2480223..2480993 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
N5O81_RS12015 (2481009) 2481009..2482343 - 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
N5O81_RS12020 (2482718) 2482718..2484289 + 1572 WP_001273939.1 galactarate dehydratase -
N5O81_RS12025 (2484438) 2484438..2484773 + 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N5O81_RS12030 (2484773) 2484773..2485237 + 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N5O81_RS12035 (2485292) 2485292..2486101 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N5O81_RS12040 (2486350) 2486350..2487630 + 1281 WP_000681930.1 tagatose-bisphosphate aldolase subunit KbaZ -
N5O81_RS12045 (2487653) 2487653..2488126 + 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
N5O81_RS12050 (2488137) 2488137..2488916 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N5O81_RS12055 (2488906) 2488906..2489784 + 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
N5O81_RS12060 (2489802) 2489802..2490236 + 435 WP_000948834.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T258169 WP_000347251.1 NZ_CP104503:2484773-2485237 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT258169 WP_001296435.1 NZ_CP104503:2484438-2484773 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References