Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4920731..4921333 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag N5O75_RS24255 Protein ID WP_000897305.1
Coordinates 4921022..4921333 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5O75_RS24250 Protein ID WP_000356397.1
Coordinates 4920731..4921021 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS24225 (4916657) 4916657..4917559 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
N5O75_RS24230 (4917556) 4917556..4918191 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N5O75_RS24235 (4918188) 4918188..4919117 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
N5O75_RS24240 (4919447) 4919447..4919689 - 243 WP_001086388.1 protein YiiF -
N5O75_RS24245 (4919908) 4919908..4920126 - 219 WP_001295676.1 CopG family transcriptional regulator -
N5O75_RS24250 (4920731) 4920731..4921021 - 291 WP_000356397.1 NadS family protein Antitoxin
N5O75_RS24255 (4921022) 4921022..4921333 - 312 WP_000897305.1 hypothetical protein Toxin
N5O75_RS24260 (4921562) 4921562..4922470 + 909 WP_001162704.1 alpha/beta hydrolase -
N5O75_RS24265 (4922534) 4922534..4923475 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N5O75_RS24270 (4923520) 4923520..4923957 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N5O75_RS24275 (4923954) 4923954..4924826 - 873 WP_000920762.1 virulence factor BrkB family protein -
N5O75_RS24280 (4924820) 4924820..4925419 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T258153 WP_000897305.1 NZ_CP104500:c4921333-4921022 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT258153 WP_000356397.1 NZ_CP104500:c4921021-4920731 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References