258139

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1937650..1938152 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N5O75_RS09275 Protein ID WP_000767829.1
Coordinates 1937898..1938152 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N5O75_RS09270 Protein ID WP_001259255.1
Coordinates 1937650..1937901 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS09245 (1932828) 1932828..1933895 - 1068 WP_038976911.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N5O75_RS09250 (1933895) 1933895..1934965 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
N5O75_RS09255 (1934962) 1934962..1936266 - 1305 WP_038976910.1 histidinol dehydrogenase -
N5O75_RS09260 (1936272) 1936272..1937171 - 900 WP_000131756.1 ATP phosphoribosyltransferase -
N5O75_RS09265 (1937317) 1937317..1937367 - 51 WP_001364200.1 his operon leader peptide -
N5O75_RS09270 (1937650) 1937650..1937901 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N5O75_RS09275 (1937898) 1937898..1938152 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N5O75_RS09280 (1938235) 1938235..1939059 + 825 WP_000754758.1 SDR family oxidoreductase -
N5O75_RS09285 (1939105) 1939105..1940034 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N5O75_RS09290 (1940249) 1940249..1940311 + 63 WP_010723108.1 membrane protein YoeI -
N5O75_RS09295 (1940301) 1940301..1941659 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N5O75_RS09300 (1941838) 1941838..1942896 + 1059 WP_000492346.1 thiosulfate utilization transporter TsuA/YeeE -
N5O75_RS09305 (1942910) 1942910..1943137 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T258139 WP_000767829.1 NZ_CP104500:1937898-1938152 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT258139 WP_001259255.1 NZ_CP104500:1937650-1937901 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References