258134

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 644182..644981 Replicon chromosome
Accession NZ_CP104500
Organism Escherichia coli strain E9

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag N5O75_RS03160 Protein ID WP_000347267.1
Coordinates 644182..644646 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N5O75_RS03165 Protein ID WP_001307405.1
Coordinates 644646..644981 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5O75_RS03130 (639183) 639183..639617 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N5O75_RS03135 (639635) 639635..640513 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
N5O75_RS03140 (640503) 640503..641282 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N5O75_RS03145 (641293) 641293..641766 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
N5O75_RS03150 (641789) 641789..643069 - 1281 WP_000681947.1 tagatose-bisphosphate aldolase subunit KbaZ -
N5O75_RS03155 (643318) 643318..644127 + 810 WP_000072180.1 aga operon transcriptional regulator AgaR -
N5O75_RS03160 (644182) 644182..644646 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N5O75_RS03165 (644646) 644646..644981 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N5O75_RS03170 (645130) 645130..646701 - 1572 WP_001273741.1 galactarate dehydratase -
N5O75_RS03175 (647076) 647076..648410 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N5O75_RS03180 (648426) 648426..649196 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T258134 WP_000347267.1 NZ_CP104500:c644646-644182 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT258134 WP_001307405.1 NZ_CP104500:c644981-644646 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References