Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4769049..4769651 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag N4229_RS23320 Protein ID WP_001159630.1
Coordinates 4769340..4769651 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4229_RS23315 Protein ID WP_000362050.1
Coordinates 4769049..4769339 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS23300 (4766542) 4766542..4767444 + 903 WP_000331362.1 formate dehydrogenase subunit beta -
N4229_RS23305 (4767441) 4767441..4768076 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
N4229_RS23310 (4768073) 4768073..4769002 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
N4229_RS23315 (4769049) 4769049..4769339 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N4229_RS23320 (4769340) 4769340..4769651 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N4229_RS23325 (4769869) 4769869..4770798 + 930 WP_057935376.1 alpha/beta hydrolase -
N4229_RS23330 (4770884) 4770884..4771195 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
N4229_RS23335 (4771192) 4771192..4771638 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
N4229_RS23340 (4771653) 4771653..4772594 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N4229_RS23345 (4772639) 4772639..4773076 - 438 WP_050068031.1 D-aminoacyl-tRNA deacylase -
N4229_RS23350 (4773073) 4773073..4773945 - 873 WP_000921423.1 virulence factor BrkB family protein -
N4229_RS23355 (4773939) 4773939..4774538 - 600 WP_000965702.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T258123 WP_001159630.1 NZ_CP104491:c4769651-4769340 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT258123 WP_000362050.1 NZ_CP104491:c4769339-4769049 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References