Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1931469..1932129 Replicon chromosome
Accession NZ_CP104491
Organism Salmonella enterica strain SalSpp_sample_05_No.1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N4229_RS09280 Protein ID WP_057935533.1
Coordinates 1931469..1931822 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4229_RS09285 Protein ID WP_057935532.1
Coordinates 1931827..1932129 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4229_RS09260 (1926532) 1926532..1927467 - 936 WP_050067699.1 hypothetical protein -
N4229_RS09265 (1927471) 1927471..1929525 - 2055 WP_057935534.1 RHS repeat-associated core domain-containing protein -
N4229_RS09270 (1929598) 1929598..1929825 + 228 Protein_1816 integrase core domain-containing protein -
N4229_RS09275 (1930451) 1930451..1931006 - 556 Protein_1817 IS630 family transposase -
N4229_RS09280 (1931469) 1931469..1931822 + 354 WP_057935533.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4229_RS09285 (1931827) 1931827..1932129 + 303 WP_057935532.1 XRE family transcriptional regulator Antitoxin
N4229_RS09290 (1932635) 1932635..1933521 + 887 Protein_1820 integrase domain-containing protein -
N4229_RS09295 (1934005) 1934005..1935267 - 1263 WP_050067692.1 integrase arm-type DNA-binding domain-containing protein -
N4229_RS09305 (1935664) 1935664..1937121 + 1458 WP_001670524.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13512.35 Da        Isoelectric Point: 9.4804

>T258113 WP_057935533.1 NZ_CP104491:1931469-1931822 [Salmonella enterica]
VWTIKTTDTFDNWFTSLNDTDRANVLAALLVLREKGPGLSRPYADTIRGSRYSNMKELRIQSRGYPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11068.87 Da        Isoelectric Point: 5.7316

>AT258113 WP_057935532.1 NZ_CP104491:1931827-1932129 [Salmonella enterica]
MGRTLEQLIADEKPEVVAEAQVMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References