258107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4611551..4612153 Replicon chromosome
Accession NZ_CP104488
Organism Salmonella enterica strain SalSpp_sample_10_No.2

Toxin (Protein)


Gene name higB Uniprot ID A0A3V8XMR3
Locus tag N4232_RS22620 Protein ID WP_001159631.1
Coordinates 4611842..4612153 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4232_RS22615 Protein ID WP_000362050.1
Coordinates 4611551..4611841 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4232_RS22600 (4609044) 4609044..4609946 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
N4232_RS22605 (4609943) 4609943..4610578 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
N4232_RS22610 (4610575) 4610575..4611504 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
N4232_RS22615 (4611551) 4611551..4611841 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N4232_RS22620 (4611842) 4611842..4612153 - 312 WP_001159631.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N4232_RS22625 (4612371) 4612371..4613300 + 930 WP_001127691.1 alpha/beta hydrolase -
N4232_RS22630 (4613386) 4613386..4613697 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
N4232_RS22635 (4613694) 4613694..4614140 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
N4232_RS22640 (4614155) 4614155..4615096 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N4232_RS22645 (4615141) 4615141..4615578 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
N4232_RS22650 (4615575) 4615575..4616447 - 873 WP_000921423.1 virulence factor BrkB family protein -
N4232_RS22655 (4616441) 4616441..4617040 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12312.25 Da        Isoelectric Point: 9.4460

>T258107 WP_001159631.1 NZ_CP104488:c4612153-4611842 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEVRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT258107 WP_000362050.1 NZ_CP104488:c4611841-4611551 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V8XMR3

Antitoxin

Source ID Structure

References