Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4774373..4775127 | Replicon | chromosome |
| Accession | NZ_CP104484 | ||
| Organism | Salmonella enterica strain SalSpp_sample_07_No.3 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | N4231_RS23370 | Protein ID | WP_000558166.1 |
| Coordinates | 4774373..4774684 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | N4231_RS23375 | Protein ID | WP_001259011.1 |
| Coordinates | 4774681..4775127 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N4231_RS23340 (4770031) | 4770031..4770933 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| N4231_RS23345 (4770930) | 4770930..4771565 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| N4231_RS23350 (4771562) | 4771562..4772491 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| N4231_RS23355 (4772538) | 4772538..4772828 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| N4231_RS23360 (4772829) | 4772829..4773140 | - | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| N4231_RS23365 (4773358) | 4773358..4774287 | + | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
| N4231_RS23370 (4774373) | 4774373..4774684 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| N4231_RS23375 (4774681) | 4774681..4775127 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| N4231_RS23380 (4775142) | 4775142..4776083 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| N4231_RS23385 (4776128) | 4776128..4776565 | - | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| N4231_RS23390 (4776562) | 4776562..4777434 | - | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
| N4231_RS23395 (4777428) | 4777428..4778027 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| N4231_RS23400 (4778218) | 4778218..4779021 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| N4231_RS23405 (4779055) | 4779055..4779951 | - | 897 | WP_001520529.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T258091 WP_000558166.1 NZ_CP104484:4774373-4774684 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT258091 WP_001259011.1 NZ_CP104484:4774681-4775127 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|