Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4772538..4773140 Replicon chromosome
Accession NZ_CP104484
Organism Salmonella enterica strain SalSpp_sample_07_No.3

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag N4231_RS23360 Protein ID WP_001159630.1
Coordinates 4772829..4773140 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4231_RS23355 Protein ID WP_000362050.1
Coordinates 4772538..4772828 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4231_RS23340 (4770031) 4770031..4770933 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
N4231_RS23345 (4770930) 4770930..4771565 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
N4231_RS23350 (4771562) 4771562..4772491 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
N4231_RS23355 (4772538) 4772538..4772828 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N4231_RS23360 (4772829) 4772829..4773140 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N4231_RS23365 (4773358) 4773358..4774287 + 930 WP_001127703.1 alpha/beta hydrolase -
N4231_RS23370 (4774373) 4774373..4774684 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
N4231_RS23375 (4774681) 4774681..4775127 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
N4231_RS23380 (4775142) 4775142..4776083 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N4231_RS23385 (4776128) 4776128..4776565 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
N4231_RS23390 (4776562) 4776562..4777434 - 873 WP_000921427.1 virulence factor BrkB family protein -
N4231_RS23395 (4777428) 4777428..4778027 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T258090 WP_001159630.1 NZ_CP104484:c4773140-4772829 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT258090 WP_000362050.1 NZ_CP104484:c4772828-4772538 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References