Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2441789..2442311 Replicon chromosome
Accession NZ_CP104484
Organism Salmonella enterica strain SalSpp_sample_07_No.3

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag N4231_RS11980 Protein ID WP_000221343.1
Coordinates 2442027..2442311 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag N4231_RS11975 Protein ID WP_000885424.1
Coordinates 2441789..2442037 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4231_RS11950 (2437005) 2437005..2438471 + 1467 WP_000987828.1 hypothetical protein -
N4231_RS11955 (2439279) 2439279..2439993 + 715 Protein_2339 helix-turn-helix domain-containing protein -
N4231_RS11960 (2440049) 2440049..2440957 - 909 WP_010989018.1 hypothetical protein -
N4231_RS11965 (2441100) 2441100..2441432 - 333 WP_000253154.1 DUF1493 family protein -
N4231_RS11970 (2441422) 2441422..2441637 - 216 WP_000206207.1 hypothetical protein -
N4231_RS11975 (2441789) 2441789..2442037 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N4231_RS11980 (2442027) 2442027..2442311 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4231_RS11985 (2442482) 2442482..2442871 + 390 WP_000194089.1 RidA family protein -
N4231_RS11990 (2442923) 2442923..2444002 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
N4231_RS11995 (2444195) 2444195..2444683 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
N4231_RS12000 (2444728) 2444728..2446236 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2437008..2449093 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T258083 WP_000221343.1 NZ_CP104484:2442027-2442311 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT258083 WP_000885424.1 NZ_CP104484:2441789-2442037 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References