Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4604498..4605100 Replicon chromosome
Accession NZ_CP104482
Organism Salmonella enterica strain SalSpp_sample_08_No.4

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag N4230_RS22390 Protein ID WP_001159635.1
Coordinates 4604789..4605100 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4230_RS22385 Protein ID WP_000362050.1
Coordinates 4604498..4604788 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4230_RS22370 (4601991) 4601991..4602893 + 903 WP_000331362.1 formate dehydrogenase subunit beta -
N4230_RS22375 (4602890) 4602890..4603525 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
N4230_RS22380 (4603522) 4603522..4604451 + 930 WP_000027736.1 formate dehydrogenase accessory protein FdhE -
N4230_RS22385 (4604498) 4604498..4604788 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N4230_RS22390 (4604789) 4604789..4605100 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N4230_RS22395 (4605318) 4605318..4606247 + 930 WP_001127705.1 alpha/beta hydrolase -
N4230_RS22400 (4606333) 4606333..4606644 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
N4230_RS22405 (4606641) 4606641..4607087 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
N4230_RS22410 (4607102) 4607102..4608043 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N4230_RS22415 (4608088) 4608088..4608525 - 438 WP_001621365.1 D-aminoacyl-tRNA deacylase -
N4230_RS22420 (4608522) 4608522..4609394 - 873 WP_000921423.1 virulence factor BrkB family protein -
N4230_RS22425 (4609388) 4609388..4609987 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T258071 WP_001159635.1 NZ_CP104482:c4605100-4604789 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT258071 WP_000362050.1 NZ_CP104482:c4604788-4604498 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References