Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 370040..370578 Replicon chromosome
Accession NZ_CP104482
Organism Salmonella enterica strain SalSpp_sample_08_No.4

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag N4230_RS01670 Protein ID WP_001526148.1
Coordinates 370303..370578 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag N4230_RS01665 Protein ID WP_000729713.1
Coordinates 370040..370300 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4230_RS01650 (365793) 365793..367346 + 1554 WP_000013013.1 TROVE domain-containing protein -
N4230_RS01655 (367694) 367694..368908 + 1215 WP_001105533.1 RNA-splicing ligase RtcB -
N4230_RS01660 (368912) 368912..369931 + 1020 WP_093984205.1 RNA 3'-terminal phosphate cyclase -
N4230_RS01665 (370040) 370040..370300 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4230_RS01670 (370303) 370303..370578 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
N4230_RS01675 (370666) 370666..373371 - 2706 WP_093984206.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T258058 WP_001526148.1 NZ_CP104482:370303-370578 [Salmonella enterica]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT258058 WP_000729713.1 NZ_CP104482:370040-370300 [Salmonella enterica]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References