Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4719286..4719888 Replicon chromosome
Accession NZ_CP104479
Organism Salmonella enterica strain SalSpp_sample_09_No.5

Toxin (Protein)


Gene name higB Uniprot ID V7IUJ1
Locus tag N4G50_RS23075 Protein ID WP_001159632.1
Coordinates 4719577..4719888 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4G50_RS23070 Protein ID WP_000362050.1
Coordinates 4719286..4719576 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G50_RS23055 (4716779) 4716779..4717681 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
N4G50_RS23060 (4717678) 4717678..4718313 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
N4G50_RS23065 (4718310) 4718310..4719239 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
N4G50_RS23070 (4719286) 4719286..4719576 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N4G50_RS23075 (4719577) 4719577..4719888 - 312 WP_001159632.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N4G50_RS23080 (4720106) 4720106..4721020 + 915 WP_024157298.1 alpha/beta hydrolase -
N4G50_RS23085 (4721046) 4721046..4721987 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N4G50_RS23090 (4722032) 4722032..4722469 - 438 WP_000560973.1 D-aminoacyl-tRNA deacylase -
N4G50_RS23095 (4722466) 4722466..4723338 - 873 WP_000921423.1 virulence factor BrkB family protein -
N4G50_RS23100 (4723332) 4723332..4723931 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12342.27 Da        Isoelectric Point: 9.4460

>T258056 WP_001159632.1 NZ_CP104479:c4719888-4719577 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT258056 WP_000362050.1 NZ_CP104479:c4719576-4719286 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4U7VQ31

Antitoxin

Source ID Structure

References