Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2468546..2469069 Replicon chromosome
Accession NZ_CP104476
Organism Staphylococcus aureus strain DSM 20231-Res2

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag N2W57_RS12290 Protein ID WP_000074048.1
Coordinates 2468546..2468812 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag N2W57_RS12295 Protein ID WP_000587616.1
Coordinates 2468812..2469069 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2W57_RS12270 (N2W57_12270) 2463853..2465040 - 1188 WP_000026194.1 MFS transporter -
N2W57_RS12275 (N2W57_12275) 2465436..2466212 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
N2W57_RS12280 (N2W57_12280) 2466205..2466867 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
N2W57_RS12285 (N2W57_12285) 2467115..2468191 - 1077 WP_001076671.1 M42 family metallopeptidase -
N2W57_RS12290 (N2W57_12290) 2468546..2468812 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
N2W57_RS12295 (N2W57_12295) 2468812..2469069 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N2W57_RS12300 (N2W57_12300) 2469428..2469883 + 456 WP_000732082.1 DUF1307 domain-containing protein -
N2W57_RS12305 (N2W57_12305) 2470051..2471628 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
N2W57_RS12310 (N2W57_12310) 2471823..2472572 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
N2W57_RS12315 (N2W57_12315) 2472796..2473989 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T258028 WP_000074048.1 NZ_CP104476:c2468812-2468546 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT258028 WP_000587616.1 NZ_CP104476:c2469069-2468812 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References