Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2437045..2437229 Replicon chromosome
Accession NZ_CP104476
Organism Staphylococcus aureus strain DSM 20231-Res2

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag N2W57_RS12150 Protein ID WP_000482650.1
Coordinates 2437122..2437229 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2437045..2437105 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2W57_RS12135 (N2W57_12135) 2432575..2432742 - 168 WP_001790576.1 hypothetical protein -
N2W57_RS12140 (N2W57_12140) 2432973..2434706 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
N2W57_RS12145 (N2W57_12145) 2434731..2436494 - 1764 WP_001064838.1 ABC transporter ATP-binding protein -
- 2437045..2437105 + 61 - - Antitoxin
N2W57_RS12150 (N2W57_12150) 2437122..2437229 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
N2W57_RS12155 (N2W57_12155) 2437363..2437749 - 387 WP_000779358.1 flippase GtxA -
N2W57_RS12160 (N2W57_12160) 2438017..2439159 + 1143 WP_001176863.1 glycerate kinase -
N2W57_RS12165 (N2W57_12165) 2439219..2439878 + 660 WP_000831298.1 membrane protein -
N2W57_RS12170 (N2W57_12170) 2440060..2441271 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
N2W57_RS12175 (N2W57_12175) 2441394..2441867 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T258027 WP_000482650.1 NZ_CP104476:c2437229-2437122 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

Antitoxin


Download         Length: 61 bp

>AT258027 NZ_CP104476:2437045-2437105 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References