258026

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2411693..2412210 Replicon chromosome
Accession NZ_CP104476
Organism Staphylococcus aureus strain DSM 20231-Res2

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag N2W57_RS12015 Protein ID WP_000113262.1
Coordinates 2411693..2411959 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag N2W57_RS12020 Protein ID WP_000584499.1
Coordinates 2411959..2412210 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2W57_RS11985 (N2W57_11985) 2407119..2407655 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
N2W57_RS11990 (N2W57_11990) 2407888..2408712 - 825 WP_000572040.1 formate/nitrite transporter family protein -
N2W57_RS11995 (N2W57_11995) 2408929..2409111 - 183 WP_000230294.1 hypothetical protein -
N2W57_RS12000 (N2W57_12000) 2409195..2409662 - 468 WP_000153344.1 SRPBCC domain-containing protein -
N2W57_RS12005 (N2W57_12005) 2409848..2411398 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
N2W57_RS12010 (N2W57_12010) 2411587..2411658 - 72 Protein_2319 hypothetical protein -
N2W57_RS12015 (N2W57_12015) 2411693..2411959 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
N2W57_RS12020 (N2W57_12020) 2411959..2412210 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N2W57_RS12025 (N2W57_12025) 2412375..2412476 - 102 WP_001791744.1 hypothetical protein -
N2W57_RS12030 (N2W57_12030) 2412483..2413082 - 600 WP_000162813.1 DsbA family protein -
N2W57_RS12035 (N2W57_12035) 2413101..2413463 - 363 WP_000819843.1 DUF4467 domain-containing protein -
N2W57_RS12040 (N2W57_12040) 2413718..2414968 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
N2W57_RS12045 (N2W57_12045) 2415065..2415796 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
N2W57_RS12050 (N2W57_12050) 2415793..2416512 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T258026 WP_000113262.1 NZ_CP104476:c2411959-2411693 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT258026 WP_000584499.1 NZ_CP104476:c2412210-2411959 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References