Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3588105..3588363 Replicon chromosome
Accession NZ_CP104472
Organism Escherichia coli strain UC4224

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag N4S17_RS17355 Protein ID WP_000809168.1
Coordinates 3588105..3588257 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3588306..3588363 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4S17_RS17335 3583346..3584059 - 714 WP_028985301.1 acidic protein MsyB -
N4S17_RS17340 3584085..3584489 - 405 WP_000843559.1 DUF2541 family protein -
N4S17_RS17345 3584866..3586782 + 1917 WP_000516135.1 molecular chaperone DnaK -
N4S17_RS17350 3586871..3588001 + 1131 WP_001118464.1 molecular chaperone DnaJ -
N4S17_RS17355 3588105..3588257 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3588306..3588363 + 58 - - Antitoxin
N4S17_RS17360 3588843..3590009 + 1167 WP_028985302.1 Na+/H+ antiporter NhaA -
N4S17_RS17365 3590075..3590974 + 900 WP_001300855.1 transcriptional activator NhaR -
N4S17_RS17370 3591013..3591972 - 960 WP_000871659.1 hypothetical protein -
N4S17_RS17375 3591985..3593337 - 1353 Protein_3390 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T258006 WP_000809168.1 NZ_CP104472:c3588257-3588105 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT258006 NZ_CP104472:3588306-3588363 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References