Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1169406..1170133 Replicon chromosome
Accession NZ_CP104471
Organism Enterobacter hormaechei strain 80014967

Toxin (Protein)


Gene name higB Uniprot ID A0A8B3V067
Locus tag NYP10_RS06755 Protein ID WP_022650547.1
Coordinates 1169822..1170133 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B3V464
Locus tag NYP10_RS06750 Protein ID WP_022650546.1
Coordinates 1169406..1169825 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP10_RS06735 (NYP10_06740) 1166478..1167599 - 1122 WP_003858868.1 YbdK family carboxylate-amine ligase -
NYP10_RS06740 (NYP10_06745) 1167705..1168595 + 891 WP_047054634.1 oxidoreductase -
NYP10_RS06745 (NYP10_06750) 1168648..1169082 - 435 WP_045342299.1 hypothetical protein -
NYP10_RS06750 (NYP10_06755) 1169406..1169825 - 420 WP_022650546.1 helix-turn-helix domain-containing protein Antitoxin
NYP10_RS06755 (NYP10_06760) 1169822..1170133 - 312 WP_022650547.1 type II toxin-antitoxin system HigB family toxin Toxin
NYP10_RS06760 (NYP10_06765) 1170589..1171245 + 657 WP_022650548.1 hypothetical protein -
NYP10_RS06765 (NYP10_06770) 1171358..1171813 - 456 WP_032657484.1 hypothetical protein -
NYP10_RS06770 (NYP10_06775) 1172095..1172976 - 882 WP_032670419.1 LysR family transcriptional regulator -
NYP10_RS06775 (NYP10_06780) 1173082..1173861 + 780 WP_026094386.1 acetolactate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12554.34 Da        Isoelectric Point: 9.9435

>T257977 WP_022650547.1 NZ_CP104471:c1170133-1169822 [Enterobacter hormaechei]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPSPDEMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKF
FIKHISTHAEYDKLTDYYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15447.51 Da        Isoelectric Point: 4.6051

>AT257977 WP_022650546.1 NZ_CP104471:c1169825-1169406 [Enterobacter hormaechei]
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVEMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3V067

Antitoxin

Source ID Structure
AlphaFold DB A0A8B3V464

References