257948

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4860720..4861322 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag N1H43_RS23685 Protein ID WP_000897305.1
Coordinates 4860720..4861031 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N1H43_RS23690 Protein ID WP_000356397.1
Coordinates 4861032..4861322 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS23655 (4855750) 4855750..4856535 + 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -
N1H43_RS23660 (4856634) 4856634..4857233 + 600 WP_001315111.1 glucose-1-phosphatase -
N1H43_RS23665 (4857227) 4857227..4858099 + 873 WP_000920762.1 virulence factor BrkB family protein -
N1H43_RS23670 (4858096) 4858096..4858533 + 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N1H43_RS23675 (4858578) 4858578..4859519 + 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N1H43_RS23680 (4859583) 4859583..4860491 - 909 WP_001162704.1 alpha/beta hydrolase -
N1H43_RS23685 (4860720) 4860720..4861031 + 312 WP_000897305.1 hypothetical protein Toxin
N1H43_RS23690 (4861032) 4861032..4861322 + 291 WP_000356397.1 NadS family protein Antitoxin
N1H43_RS23695 (4861927) 4861927..4862145 + 219 WP_001295676.1 CopG family transcriptional regulator -
N1H43_RS23700 (4862364) 4862364..4862606 + 243 WP_001086388.1 protein YiiF -
N1H43_RS23705 (4862936) 4862936..4863865 - 930 WP_000027702.1 formate dehydrogenase accessory protein FdhE -
N1H43_RS23710 (4863862) 4863862..4864497 - 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N1H43_RS23715 (4864494) 4864494..4865396 - 903 WP_000331377.1 formate dehydrogenase O subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T257948 WP_000897305.1 NZ_CP104442:4860720-4861031 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT257948 WP_000356397.1 NZ_CP104442:4861032-4861322 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References