257944

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4042905..4043704 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag N1H43_RS19670 Protein ID WP_000347267.1
Coordinates 4043240..4043704 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N1H43_RS19665 Protein ID WP_001307405.1
Coordinates 4042905..4043240 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS19650 (4038690) 4038690..4039460 - 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -
N1H43_RS19655 (4039476) 4039476..4040810 - 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N1H43_RS19660 (4041185) 4041185..4042756 + 1572 WP_001273741.1 galactarate dehydratase -
N1H43_RS19665 (4042905) 4042905..4043240 + 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N1H43_RS19670 (4043240) 4043240..4043704 + 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N1H43_RS19675 (4043759) 4043759..4044568 - 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N1H43_RS19680 (4044817) 4044817..4046097 + 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
N1H43_RS19685 (4046120) 4046120..4046593 + 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N1H43_RS19690 (4046604) 4046604..4047383 + 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N1H43_RS19695 (4047373) 4047373..4048251 + 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
N1H43_RS19700 (4048269) 4048269..4048703 + 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4033870..4043704 9834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T257944 WP_000347267.1 NZ_CP104442:4043240-4043704 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT257944 WP_001307405.1 NZ_CP104442:4042905-4043240 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References