257940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2764403..2764905 Replicon chromosome
Accession NZ_CP104442
Organism Escherichia coli strain HBUT-L

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N1H43_RS13570 Protein ID WP_000767829.1
Coordinates 2764403..2764657 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N1H43_RS13575 Protein ID WP_001259255.1
Coordinates 2764654..2764905 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H43_RS13540 (2759418) 2759418..2759645 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
N1H43_RS13545 (2759659) 2759659..2760717 - 1059 WP_000492346.1 thiosulfate utilization transporter TsuA/YeeE -
N1H43_RS13550 (2760896) 2760896..2762254 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N1H43_RS13555 (2762244) 2762244..2762306 - 63 WP_010723108.1 membrane protein YoeI -
N1H43_RS13560 (2762521) 2762521..2763450 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N1H43_RS13565 (2763496) 2763496..2764320 - 825 WP_000754749.1 SDR family oxidoreductase -
N1H43_RS13570 (2764403) 2764403..2764657 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N1H43_RS13575 (2764654) 2764654..2764905 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N1H43_RS13580 (2765188) 2765188..2765238 + 51 WP_001364200.1 his operon leader peptide -
N1H43_RS13585 (2765384) 2765384..2766283 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
N1H43_RS13590 (2766289) 2766289..2767593 + 1305 WP_001349967.1 histidinol dehydrogenase -
N1H43_RS13595 (2767590) 2767590..2768660 + 1071 WP_000108957.1 histidinol-phosphate transaminase -
N1H43_RS13600 (2768660) 2768660..2769727 + 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T257940 WP_000767829.1 NZ_CP104442:c2764657-2764403 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT257940 WP_001259255.1 NZ_CP104442:c2764905-2764654 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References