Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1696707..1697314 Replicon chromosome
Accession NZ_CP104408
Organism Pseudomonas fluorescens strain Ant01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N4P55_RS07740 Protein ID WP_262667977.1
Coordinates 1696707..1696982 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A172YY36
Locus tag N4P55_RS07745 Protein ID WP_064451284.1
Coordinates 1697021..1697314 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4P55_RS07710 (N4P55_07725) 1691976..1692308 - 333 WP_262667268.1 hypothetical protein -
N4P55_RS07715 (N4P55_07730) 1692394..1692804 - 411 WP_064451279.1 type II toxin-antitoxin system HicB family antitoxin -
N4P55_RS07720 (N4P55_07735) 1692827..1693009 - 183 WP_262667269.1 type II toxin-antitoxin system HicA family toxin -
N4P55_RS07725 (N4P55_07740) 1693175..1694068 - 894 WP_262667270.1 LysR family transcriptional regulator -
N4P55_RS07730 (N4P55_07745) 1694164..1695327 + 1164 WP_262667271.1 MFS transporter -
N4P55_RS07735 (N4P55_07750) 1695324..1696460 + 1137 WP_262667272.1 MFS transporter -
N4P55_RS07740 (N4P55_07755) 1696707..1696982 + 276 WP_262667977.1 hypothetical protein Toxin
N4P55_RS07745 (N4P55_07760) 1697021..1697314 + 294 WP_064451284.1 helix-turn-helix domain-containing protein Antitoxin
N4P55_RS07750 (N4P55_07765) 1697334..1697537 - 204 WP_262667273.1 hypothetical protein -
N4P55_RS07755 (N4P55_07770) 1697970..1698209 + 240 WP_064451286.1 DUF6124 family protein -
N4P55_RS07760 (N4P55_07775) 1698291..1698596 - 306 WP_221294183.1 DUF6482 family protein -
N4P55_RS07765 (N4P55_07780) 1698620..1699144 - 525 WP_064451288.1 DUF3833 domain-containing protein -
N4P55_RS07775 (N4P55_07790) 1699629..1700513 - 885 WP_262667274.1 alpha/beta hydrolase -
N4P55_RS07780 (N4P55_07795) 1700818..1701510 - 693 WP_262667275.1 pseudouridine synthase -
N4P55_RS07785 (N4P55_07800) 1701510..1701722 - 213 WP_064451291.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10290.88 Da        Isoelectric Point: 6.9757

>T257920 WP_262667977.1 NZ_CP104408:1696707-1696982 [Pseudomonas fluorescens]
VIFVESPVFTEDLPALLSEESYGEFQEFLAENPTAGDVIQGTNGLRKIRWAVQGRGKRGGVRVIYYHLCMAYQIRLILIY
RKGIKDDLSAV

Download         Length: 276 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10986.60 Da        Isoelectric Point: 9.8595

>AT257920 WP_064451284.1 NZ_CP104408:1697021-1697314 [Pseudomonas fluorescens]
MEKKLFNRLVESMTQMDEIARGERAPSREFFVDALKVKEIRQATGLSQARFAKAIDVPVGTLQNWEQGRREPEGPAKALL
RALYNDPDHVLAALGHR

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A172YY36

References