Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2957226..2957886 Replicon chromosome
Accession NZ_CP104405
Organism Enterobacter hormaechei subsp. steigerwaltii strain 4236

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0Q4X0
Locus tag N5F16_RS14335 Protein ID WP_017383312.1
Coordinates 2957533..2957886 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0Q4Z7
Locus tag N5F16_RS14330 Protein ID WP_017383313.1
Coordinates 2957226..2957528 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F16_RS14315 (N5F16_14315) 2953400..2954725 + 1326 WP_017383315.1 SidA/IucD/PvdA family monooxygenase -
N5F16_RS14320 (N5F16_14320) 2954752..2956941 + 2190 WP_033486921.1 TonB-dependent siderophore receptor -
N5F16_RS14330 (N5F16_14330) 2957226..2957528 - 303 WP_017383313.1 XRE family transcriptional regulator Antitoxin
N5F16_RS14335 (N5F16_14335) 2957533..2957886 - 354 WP_017383312.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5F16_RS14340 (N5F16_14340) 2958077..2959027 - 951 WP_017383311.1 HTH-type transcriptional regulator Cbl -
N5F16_RS14345 (N5F16_14345) 2959124..2960041 - 918 WP_003859531.1 nitrogen assimilation transcriptional regulator NAC -
N5F16_RS14355 (N5F16_14355) 2960575..2961507 - 933 WP_133982975.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13537.37 Da        Isoelectric Point: 9.9538

>T257912 WP_017383312.1 NZ_CP104405:c2957886-2957533 [Enterobacter hormaechei subsp. steigerwaltii]
VWAIKTTDRFDDWFTSLNDSERASVLAALLVLRERGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNERRFYDEMLLVADREYTRWLNTLKERN

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11028.85 Da        Isoelectric Point: 6.4727

>AT257912 WP_017383313.1 NZ_CP104405:c2957528-2957226 [Enterobacter hormaechei subsp. steigerwaltii]
MGRTLEQLIADEKPEVVASAQAMATDILLNIHLAELREKVQKTQVDMARALGIKQPTVAVMEKAGRDIKLSSLKRYVEAA
GGKLRLDVELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0Q4X0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0Q4Z7

References