Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3640791..3641466 Replicon chromosome
Accession NZ_CP104403
Organism Enterobacter hormaechei subsp. steigerwaltii strain csa13R

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag N5F14_RS17550 Protein ID WP_015571638.1
Coordinates 3640791..3641090 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag N5F14_RS17555 Protein ID WP_015571639.1
Coordinates 3641101..3641466 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5F14_RS17540 (N5F14_17540) 3637168..3639360 + 2193 WP_017692801.1 type I secretion system permease/ATPase -
N5F14_RS17545 (N5F14_17545) 3639341..3640540 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
N5F14_RS17550 (N5F14_17550) 3640791..3641090 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5F14_RS17555 (N5F14_17555) 3641101..3641466 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
N5F14_RS17560 (N5F14_17560) 3641493..3642674 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
N5F14_RS17565 (N5F14_17565) 3642695..3643582 - 888 WP_015571641.1 LysR family transcriptional regulator -
N5F14_RS17570 (N5F14_17570) 3643680..3644282 + 603 WP_017382759.1 short chain dehydrogenase -
N5F14_RS17575 (N5F14_17575) 3644279..3645010 - 732 WP_039269965.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T257895 WP_015571638.1 NZ_CP104403:3640791-3641090 [Enterobacter hormaechei subsp. steigerwaltii]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT257895 WP_015571639.1 NZ_CP104403:3641101-3641466 [Enterobacter hormaechei subsp. steigerwaltii]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References