257853

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1027027..1027654 Replicon chromosome
Accession NZ_CP104386
Organism Cupriavidus gilardii strain WM02

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag N4G38_RS04790 Protein ID WP_082371643.1
Coordinates 1027373..1027654 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4G38_RS04785 Protein ID WP_269465298.1
Coordinates 1027027..1027380 (-) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4G38_RS04770 (N4G38_04770) 1022970..1025852 + 2883 WP_260731143.1 formate dehydrogenase subunit alpha -
N4G38_RS04775 (N4G38_04775) 1025941..1026747 + 807 WP_260731431.1 formate dehydrogenase accessory sulfurtransferase FdhD -
N4G38_RS04780 (N4G38_04780) 1026750..1026971 + 222 WP_053822308.1 formate dehydrogenase subunit delta -
N4G38_RS04785 (N4G38_04785) 1027027..1027380 - 354 WP_269465298.1 HigA family addiction module antitoxin Antitoxin
N4G38_RS04790 (N4G38_04790) 1027373..1027654 - 282 WP_082371643.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4G38_RS04795 (N4G38_04795) 1027798..1028265 - 468 WP_053822307.1 MgtC/SapB family protein -
N4G38_RS04800 (N4G38_04800) 1028418..1029113 - 696 WP_174782019.1 transglycosylase domain-containing protein -
N4G38_RS04805 (N4G38_04805) 1029427..1030563 - 1137 WP_053822306.1 HPP family protein -
N4G38_RS04810 (N4G38_04810) 1030745..1031563 + 819 WP_053822305.1 TOBE domain-containing protein -
N4G38_RS04815 (N4G38_04815) 1031660..1032337 - 678 WP_174782017.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - sodB / siaC/synC / htpB 925561..1152522 226961


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(22-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(19-109)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10702.35 Da        Isoelectric Point: 8.7701

>T257853 WP_082371643.1 NZ_CP104386:c1027654-1027373 [Cupriavidus gilardii]
MIQSFRCMDTRALFEGKRVARFTNIHAVAERKLQMLESATTLASLMAPPGNRLEILSGNRRGQYSIRVNAQWRICFLWTS
EGPQCVEIVDYHD

Download         Length: 282 bp

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 12948.65 Da        Isoelectric Point: 4.6133

>AT257853 WP_269465298.1 NZ_CP104386:c1027380-1027027 [Cupriavidus gilardii]
MIEFNNNVGEEFAMARFHNGMRPVHPGEILREEYLVPLDLSIAELAKELHIDTAQIDAIVRGDAGVASEIALRLARYFGG
DAETWLNLQQAYDLKTAEQQVGDAIRSEVAPRKAKAA

Download         Length: 354 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References