Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2335197..2336785 | Replicon | chromosome |
Accession | NZ_CP104384 | ||
Organism | Escherichia coli strain JNQH498 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | S1ELM3 |
Locus tag | KIG00_RS11460 | Protein ID | WP_001125439.1 |
Coordinates | 2335463..2336785 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | KIG00_RS11455 | Protein ID | WP_001301023.1 |
Coordinates | 2335197..2335463 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KIG00_RS11455 (2335197) | 2335197..2335463 | + | 267 | WP_001301023.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
KIG00_RS11460 (2335463) | 2335463..2336785 | + | 1323 | WP_001125439.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
KIG00_RS11465 (2337097) | 2337097..2337305 | + | 209 | Protein_2242 | AraC family transcriptional regulator | - |
KIG00_RS11470 (2337560) | 2337560..2338786 | + | 1227 | Protein_2243 | fimbria/pilus outer membrane usher protein | - |
KIG00_RS11475 (2338800) | 2338800..2339330 | + | 531 | WP_000876763.1 | fimbrial protein | - |
KIG00_RS11480 (2339343) | 2339343..2339846 | + | 504 | WP_000825452.1 | fimbrial protein | - |
KIG00_RS11485 (2339905) | 2339905..2340819 | + | 915 | WP_000520676.1 | fimbrial protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 2335197..2348006 | 12809 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49275.82 Da Isoelectric Point: 8.2482
>T257843 WP_001125439.1 NZ_CP104384:2335463-2336785 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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