Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 713634..714327 Replicon chromosome
Accession NZ_CP104384
Organism Escherichia coli strain JNQH498

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KIG00_RS03475 Protein ID WP_000415584.1
Coordinates 713634..713930 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KIG00_RS03480 Protein ID WP_000650107.1
Coordinates 713932..714327 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KIG00_RS03440 (708722) 708722..709036 - 315 WP_000958598.1 putative quinol monooxygenase -
KIG00_RS03445 (709067) 709067..709648 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KIG00_RS03450 (709967) 709967..710299 + 333 WP_000917684.1 DUF2645 family protein -
KIG00_RS03455 (710345) 710345..711694 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KIG00_RS03460 (711691) 711691..712350 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KIG00_RS03465 (712502) 712502..712894 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KIG00_RS03470 (712947) 712947..713429 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KIG00_RS03475 (713634) 713634..713930 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KIG00_RS03480 (713932) 713932..714327 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KIG00_RS03485 (714460) 714460..716067 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KIG00_RS03490 (716205) 716205..718463 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T257833 WP_000415584.1 NZ_CP104384:713634-713930 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT257833 WP_000650107.1 NZ_CP104384:713932-714327 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References