Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 711236..712011 Replicon chromosome
Accession NZ_CP104373
Organism Klebsiella pneumoniae strain 2021CK-01815

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A331A5C5
Locus tag N4558_RS03510 Protein ID WP_019704987.1
Coordinates 711526..712011 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag N4558_RS03505 Protein ID WP_004150912.1
Coordinates 711236..711529 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4558_RS03485 (N4558_03485) 706445..707047 - 603 WP_019704985.1 short chain dehydrogenase -
N4558_RS03490 (N4558_03490) 707145..708056 + 912 WP_017879796.1 LysR family transcriptional regulator -
N4558_RS03495 (N4558_03495) 708057..709205 - 1149 WP_019704986.1 PLP-dependent aspartate aminotransferase family protein -
N4558_RS03500 (N4558_03500) 709216..710592 - 1377 WP_017879795.1 pyridoxal-phosphate dependent enzyme -
N4558_RS03505 (N4558_03505) 711236..711529 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
N4558_RS03510 (N4558_03510) 711526..712011 + 486 WP_019704987.1 GNAT family N-acetyltransferase Toxin
N4558_RS03515 (N4558_03515) 712715..713308 + 594 WP_004188553.1 hypothetical protein -
N4558_RS03520 (N4558_03520) 713405..713621 + 217 Protein_691 transposase -
N4558_RS03530 (N4558_03530) 714462..715175 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 713405..713557 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17572.56 Da        Isoelectric Point: 8.5111

>T257816 WP_019704987.1 NZ_CP104373:711526-712011 [Klebsiella pneumoniae]
MISAPEPLNAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT257816 WP_004150912.1 NZ_CP104373:711236-711529 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331A5C5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References